Under Construction -- Later perhaps abstracts of each will appear.
Research Projects at UCI I have contributed to:
DNA Nanotechnology
-Design and characterization of DNA nanostructures
Multiplex PCR
-Algorithm for multiplex PCR primer design
-Greed heuristic, outpeforms generic search algorithms by many orders of magnitude
Synthetic Gene Construction (CODA Genomics)
-Distrubuted thermodynamic predictions
-Error rate reduction
Site-directed Mutagenesis
-Computational prediction of success/failure
-Improvement of efficiency
Broad interests:
Machine Learning
Data Mining
Computational Biology
Systems Biology
Biophysics
Artificial Intelligence
Financial Markets
Publications:
- "Computationally Optimized DNA Assembly of Synthetic Genes," Larsen, L.S. Z., Wassman, C.D., Hatfield, G.W., and Lathrop, R.H. (submitted)
- "Predicting oligonucleotide-directed mutagenesis failures in protein engineering," Wassman, C.D., Tam, P.Y., Lathrop, R.H., Weiss, G.A., Nucleic Acids Res., (2004).
Patents:
- "Method for producing a synthetic gene or other DNA sequence," Lathrop, Richard H.; Larsen, Liza S.Z.; Wassman, Christopher; Hatfield, G. Wesley; United States patent application #20050106590 (submitted 2005).
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