| Bioinformatics | Neural Networks | Machine Learning |
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Incorporating existing network information into gene network
inference Christley S, Nie Q and Xie X PLoS ONE 4(8): e6799. doi:10.1371/journal.pone.0006799 (2009) |
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Genome-wide analysis of SREBP-1 binding in mouse liver chromatin
reveals a preference for promoter proximal binding to a new motif
Seo YK, Chong HK, Infante AM, Im S, Xie X, and Osborne TF Proc Natl Acad Sci USA doi:10.1073/pnas.0904246106 (2009) |
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Identifying novel constrained elements by exploiting biased
substitution patterns Garber M, Guttman1 M, Clamp M, Zody MG, Friedman N, and Xie X Bioinformatics 25:i54-i62 (2009) Supplementary Methods SiPhy (SIte-specific PHYlogenetic analysis) Java software package |
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Comparative
genomics allows the discovery of cis-regulatory elements in mosquitoes Sieglaff DH, Dunn WA, Xie X, Megy K, Marinotti O, and James AA Proc Natl Acad Sci USA doi:10.1073/pnas.0813264106 (2009) |
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Common polymorphic transcript variation in human disease Fraser H and Xie X Genome Research doi:10.1101/gr.083477.108 (2009) |
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MotifMap: a human genome-wide map of candidate regulatory motif sites Xie X, Rigor P, and Baldi P Bioinformatics 25: 167-174 (2009) PDF Supplementary Methods MotifMap Server |
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Human genomes as email attachments Christley S, Lu Y, Li C, and Xie X Bioinformatics 25: 274-275 (2009) DNAzip: DNA sequence compression using a reference genome News featured in genomeweb |
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Discovering regulatory motifs in the Plasmodium genome using
comparative genomics Wu J, Sieglaff DH, Gervin J, and Xie X Bioinformatics 24:1843-9 (2008) MDOS software: A method for Motif Discovery using Orthologous Sequences (alignment independent). Supplementary Information on the MDOS algorithm |
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Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, Koseki H, Bernstein BE PLoS Genetics 4(10):e1000242 (2008) |
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Distinguishing protein-coding and noncoding genes in the human genome Clamp M, Fry B, Kamal M, Xie X, Cuff J, Lin MF, Kellis M, Lindblad-Toh K, and Lander ES. Proc Natl Acad Sci USA 104(49):19428-33 (2007) |
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Genome-wide detection and characterization of positive
selection in human populations Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF, Lander ES and International HapMap Consortium Nature 449:913-918 (2007) |
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Geome-wide maps of chromatin state in pluripotent and
lineage-committed cells
Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, Alvarez P, Brockman W, Kim TK, Koche RP, Lee W, Mendenhall E, O'Donovan A, Presser A, Russ C, Xie X, Meissner A, Wernig M, Jaenisch R, Nusbaum C, Lander ES, Bernstein BE. Nature 448:553-60 (2007) |
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Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites
Xie X, Mikkelsen TS, Gnirke A, Lindblad-Toh K, Kellis M and Lander ES. Proc Natl Acad Sci USA 104:7145-7150 (2007) Supplementary website Supporting Information News story |
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Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
Mikkelsen TS, Wakefield MJ, et al. Nature 447:167-177 (2007) |
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A family of conserved noncoding elements derived from an ancient transposable element Xie X, Kamal M, and Lander ES. Proc Natl Acad Sci USA 103:11659-11664 (2006) Supplementary website Supporting Information News story |
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A large family of ancient repeat elements in the human genome is under
strong selection Kamal M, Xie X, and Lander ES. Proc Natl Acad Sci USA 103:2740-2745 (2006) Supplementary website Supporting Information News story |
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A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells Bernstein BE, Mikkelsen TS, Xie X, Kamal M et al. Cell 125:315-26 (2006) |
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Comparative sequence analysis reveals an intricate network among REST,
CREB and miRNA in mediating neuronal gene expression Wu J and Xie X Genome Biology 7(9):R85 (2006) (Highly accessed) Supplementary website |
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Systematic identification of human mitochondrial disease genes through
integrative genomics Calvo S, Jain M, Xie X, Chang B, Spinazzola A, Zeviani M, Carr S, and Mootha VK. Nature Genetics, 38:576-82 (2006) |
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Systematic discovery of regulatory motifs in
human promoters and 3' UTRs by comparison of several
mammals Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha VK, Lindblad-Toh K, Lander ES, Kellis M. Nature 2005; 434:338-45 Supplementary Website Supplementary Information News story |
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A molecular-properties-based approach to understanding PDZ domain
proteins and PDZ ligands Giallourakis C, Cao Z, Green T, Wachtel H, Xie X, Lopez-Illasaca M, Daly M, Rioux J, Xavier R. Genome Resesarch, 16:1056-72 (2006) |
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A Mammalian Organelle Map by Protein Correlation Profiling Foster LJ, de Hoog CL, Zhang Y, Zhang Y, Xie X, Mootha VK, and Mann M. Cell 125:187-99 (2006) |
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Learning curves for stochastic gradient descent in linear feedforward networks. Werfel J, Xie X and Seung HS. Neural Computation, 2005;17:2699-718 |
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Genome sequence, comparative analysis and haplotype structure of the
domestic dog Lindblad-Toh K, Wade CM, et al. Nature 438:803-19 2005 |
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Disease gene discovery through integrative genomics. Giallourakis C, Henson C, Reich M, Xie X, and Mootha VK. Annu. Rev. Genomics Hum. Genet. 2005:22:381-406. |
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Learning in neural networks by reinforcement of irregular spiking. Xie X and Seung HS. Phys Rev E, 2004;69:041909 |
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Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation
gene expression that is altered in diabetic muscle Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J et al. Proc Natl Acad Sci USA, 2004;101:6570-5 |
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The double-ring network modeling of the head-direction system Xie X, Hahnloser RH, and Seung HS. Physical Review E, 2002;66:041902 |
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Nonlinear dynamics of direction-selective recurrent neural media Xie X and Giese MA. Physical Review E, 2002;65:051904 |
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Exact solution of the nonlinear dynamics of recurrent neural mechanisms for direction selectivity Giese MA and Xie X Neurocomputing 2002;44:417-422 |
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Learning winner-take-all competition between groups of neurons in lateral inhibitory
networks Xie X, Hahnloser HR, and Seung HS. Advances in Neural Information Processing Systems 2001;13:350-356 |
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Generating velocity tuning by asymmetric recurrent connections Xie X and Giese MA. Advances in Neural Information Processing Systems 2002;13:325-332 |
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Selectively Grouping Neurons in Recurrent Networks of Lateral Inhibition Xie X, Hahnloser RH, and Seung HS. Neural Computation, 2002;14:2627-2646 |
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Equivalence of backpropagation and contrastive Hebbian learning in a layered network Xie X and Seung HS. Neural Computation, 2003;16:441-454 |
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Threshold behavior of maximum likelihood method in population decoding Xie X Network: Comput. Neural Syst. 2002;13:447-456 |
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Spike-based learning rules and stabilization of persistent neural activity Xie X and Seung HS Advances in Neural Information Processing Systems 2000;12:199-205 |