Zhaoxia Yu, Ph.D.
zhaoxia ics.uci.edu |
Research Interests
Statistical methods and applications.
Lecture
materials for intro to mixed-effects models (Feb 2023)
Slides for
intro-to-stat talk for a UCI research club (Jan 2022)
Lecture materials for CNCM 2023 (Aug 2023): web, zip
Current Teaching
I will be teaching Statistics 200A and 200AP in Fall
2023.
Courses that I taught before: STAT8, STAT120A/B/C,
STAT140/240, STAT257, STAT262, STAT200A/B/C
Some Recent Work
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Au DD, Foden AJ, Park SJ, Nguyen TH, Liu JC,
Tran MD, Olga G. Jaime, Yu Z, and Holmes TC. (2022) Mosquito Cryptochromes
expressed in Drosophila confer species-specific behavioral light responses. Current
Biology. In print.
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Feng J, Zhang L, Chen C, Sheng J, Ye Z, Feng
K, Liu J, Cai Y, Zhu B, Yu Z, Chen C, Dong Q, Xue G. (2022) A cognitive
neurogenetic approach to uncovering the structure of executive functions. Nature
Communications. In print.
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Wu K, Chen C, Yu Z. (2022) Handsome or
Rugged? A Speed-dating Study of Ovulatory Shifts in Womens Preferences for
Masculinity in Men. Under revision for Human Nature.
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Gauran I, Xue G, Chen C, Ombao H, Yu Z.
(2022) Ridge Penalization in High-Dimensional Testing with applications to
Imaging Genetics. Frontiers in Neuroscience 16:836100.
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D'Angelo L, Canale A, Yu Z, Guindani M.
(2022) Bayesian nonparametric analysis for the detection of spikes in noisy
calcium imaging data. Biometrics. In print.
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Yu Z, Guindani M, Grieco SF, Chen L, Holmes TC, Xu X.
(2022) Beyond t-Test and ANOVA: applications of mixed-effects models for more
rigorous statistical analysis in neuroscience research. Neuron. 110: 21-23.
Data and web-based
supplemental materials are available from
https://yu-zhaoxia.github.io/MM_in_Neuroscience/
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Shen T, Lur G, Xu X, Yu Z. (2022) To
Deconvolve, or Not to Deconvolve: Inferences of Neuronal Activities using
Calcium Imaging Data. Journal
Neuroscience Methods. 366: 109431
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Shen, Johnston K, Lur G, Guidani M, Ombao H,
Xu X, Yu Z. (2021) Time-varying ℓ0 optimization for Spike
Inference from Multi-Trial Calcium Recordings. Submitted. arXiv preprint. arXiv:2103.03818
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Pluta D, Xu X, Gillen D, Yu Z. (2021).
A
Measurement of In-Betweenness and Inference Based on Shape Theories. Submitted.
arXiv preprint. arXiv:2103.09718
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Brandt AU, Sy M, Bellmann-Strobl J, Newton BL,
Pawling J, Zimmermann HG, Yu Z, Chien C, Dorr J, Wuerfel JT, Dennis JW,
Paul F, Demetriou M (2021) Association of a Marker of N-Acetylglucosamine With
Progressive Multiple Sclerosis and Neurodegeneration. JAMA Neurology.
78:842-852.
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Pluta D, Shen T, Xue G, Chen C, Ombao H, Yu
Z. (2021) Ridge-penalized adaptive Mantel test and its application in
imaging genetics. Statistics in Medicine. 40:5313-5332.
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Grieco SF, Qiao X, Zheng X, Liu Y, Chen L,
Zhang H, Yu, Z, Gavornik JP, Lai C, Gandhi SP, Holmes TC. (2020).
Subanesthetic ketamine reactivates adult cortical plasticity to restore vision
from amblyopia. Current Biology, 30:3591-3603.
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Feng J, Chen C, Cai Y, Ye Z, Feng K, Liu J,
Zhang L, Yang Q, Li A, Sheng J, Zhu B, Yu Z, Chen C, Dong Q, Xue G.
(2020) Partitioning heritability analyses unveil the genetic architecture of
human brain multidimensional functional connectivity patterns. Human Brain
Mapping. 41:3305-3317.
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Sy M, Brandt AU, Lee SU, Newton BL, Pawling J,
Golzar A, Rahman AM, Yu Z, Cooper G, Scheel M, Paul, F. (2020).
N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor
cell differentiation. Journal of Biological Chemistry, 295:17413-17424.
Older Articles (selected)
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Pluta D, Yu
Z, Shen T, Chen C, Xue G, Ombao H. (2018) Statistical Methods and
Challenges in Connectome Genetics. Statistics
and Probability Letters. 136:83-86
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Interiano M, Kazemi K, Wang L, Yang J, Yu Z, Komarova NL. (2018) Musical
trends and predictability of success in contemporary songs on and off the top
charts. To appear in Royal Society Open
Science, 5: 171274.
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Wu K, Chen C, Moyzis RK, Nuno M, Yu Z, Greenberger E. (2018) More than
Skin Deep: Uncovering Major Histocompatibility Complex (MHC)-Based Attraction
among Asian American Speed-daters. Evolution
and Human Behavior, 39(4):447-456.
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Wu K, Chen C, Moyzis RK, Greenberger E, Yu Z. (2016) Gender Interacts with
Opioid Receptor Polymorphism A118G and Serotonin Receptor Polymorphism -1438A/G
on Speed-dating Success. Human Nature,
27(3):244-60.
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Yu Z, Demetriou M,
Gillen D. (2015) Genome-wide analysis of gene-gene and gene-environment
interactions using closed-form Wald tests. Genetic
Epidemiology, 39: 446-455.
(software: GG_Wald)
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Yu Z, Li CF,
Mkhikian H, Zhou RW, Newton BL, Demetriou M. (2014) Family studies of Type 1
diabetes reveal additive and epistatic effects between MGAT1 and three other
polymorphisms. Genes and Immunity,
15:218-223.
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Yu Z, Gillen D, Li
CF, Demetriou M. (2013) Incorporating parental information into family-based
association tests. Biostatistics,
14: 556-572.supplementary material
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Yu Z (2012).
Family-based association tests using genotype data with uncertainty. Biostatistics, 13:228-240.
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Shahbaba B, Shachaf
CM, Yu Z. (2012) A pathway analysis
method for genome-wide association studies. Statistics
in Medicine, 31:988-1000.
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Yu Z, Deng L.
(2011) Pseudosibship methods in the case-parents design. Statistics in Medicine, 30:3236-3251.
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Yu Z, Wang S
(2011). Contrasting linkage-disequilibrium as a multi-locus family-based
association test. Genetic Epidemiology,
35:487-498.
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Yu Z (2011).
Testing gene-gene interactions in the case-parents design. Human Heredity, 71:171-179.
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Weng L, Macciardi F,
Subramanian A, Guffanti G, Potkin SG, Yu
Z, Xie X. (2011) SNP-based pathway enrichment analysis for genome-wide
association studies. BMC Bioinformatics,
12:99.
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Browning B, Yu Z. (2009). Simultaneous genotype
calling and haplotype phasing improves genotype accuracy and reduces false
positive associations for genome-wide association studies. American Journal of Human Genetics, 85:847-861.
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Yu Z, Garner C,
Ziogas A, Anton-Culver H, Schaid D. (2009). Genotype determination for
polymorphisms in linkage disequilibrium. BMC
Bioinformatics, 10:63.
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Yu Z, Wang L,
Hildebrandt MAT, Schaid D. (2008). Testing whether genetic variation explains
correlation of quantitative measures of gene expression, and application to
genetic network analysis. Statistics in
Medicine, 27:3847 - 3867.
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Yu Z, Schaid D.
(2007). Methods to impute missing genotypes for population data. Human Genetics, 122:495-504.
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Yu Z, Schaid D.
(2007). Sequential haplotype scan methods for association analysis. Genetic Epidemiology, 31: 553-564.
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Levine R, Yu Z, Hanley W, Nitao J. (2005).
Implementing componentwise Hastings algorithms, Computational Statistics &
Data Analysis, 48: 363-389.
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Levine R, Yu Z, Hanley W, Nitao J. (2005).
Implementing the random scan Gibbs sampler, Computational Statistics, 20:
177-196
(taken in November 2018)