Organized research programs provide a mechanism and organizational structure within which collective research activities can take place that are fundamentally different from those that occur normally within the schools and departments. They are intended to foster the development of short- and long-term research programs that span disciplines and academic units, thereby making it possible for faculty to acquire extramural resources for which they might not otherwise qualify. The following is a list of the research centers that are part of ICS:

ABRC - Ada Byron Research Center
ABRC studies and promotes diverse access to and participation in computer science, engineering, digital media and related information technology fields.

Calit2 - California Institute for Telecommunications and Information Technology
A multidisciplinary research institute in collaboration with UCSD, Calit2@UCI integrates academic research with industry experience to seek innovative IT approaches that will benefit society and ignite economic development.

CDT - Center for Digital Transformation
One of the world's leading think tanks on the impact of information technology on organizations and society and on the management of information technology.

Center for Algorithms and Theory of Computation
The goal of research in theoretical computer science is to produce results, supported by rigorous proof, about problems dealing with computers and their applications.

Center for Embedded Computer Systems
Conducting leading-edge interdisciplinary research in embedded systems, the center develops innovative design methodologies, and promote technology and knowledge transfer for the benefit of the individual and society.

Center for Machine Learning and Intelligent Systems
Addresses the challenges of the modern data-driven world, using computer algorithms to discover useful information from vast data archives.

Center for Social Computing
Conducts foundational research into the relationship between information technology and society. Based at UCI, the center brings together an interdisciplinary group of researchers from leading U.S. universities.

CERT - Center for Emergency Response Technologies
Works to radically transform the ability of responding organizations to gather, manage, use, and disseminate information within emergency response networks and to the general public. By using more robust information systems, response can focus on activities that have the highest potential to save lives and property.

Connected Learning Lab
The Connected Learning Lab is dedicated to studying and mobilizing learning technologies in equitable, innovative, and learner-centered ways. Over 30 faculty are members of the CLL, representing a diverse range of disciplines and departments, including Anthropology, Comparative Literature, Computer Science, Education, English, Informatics, Nursing, Psychological Sciences, and Sociology.

COR - Center for Organizational Research
COR contributes to the development of organization theory by connecting scholars from many disciplines who bring their knowledge and methods to a common understanding of these issues.

CPCC - Center for Pervasive Communications and Computing
Dedicated to serving the vision of wearable computers with wireless connections that enable anyone to have continuous voice, video, and data connectivity.

CPRI - Cybersecurity Policy & Research Institute 
CPRI is a multidisciplinary, collaborative effort among UCI's schools of Information and Computer Sciences, Engineering, Law, Physical Sciences, Social Ecology, Social Sciences and the Division of Continuing Education. It brings a holistic, focus to difficult technology, legal and policy challenges in combatting cyber threats, while working to protect individual privacy and civil liberties.

Computational Vision Lab
The Computational Vision Lab focuses on understanding the information processing capabilities of biological visual systems and on developing computational systems for processing visual media.

CREATE – UCI’s Steckler Center for Responsible, Ethical, and Accessible Technology
The Steckler Center for Responsible, Ethical, and Accessible Technology (CREATE) promotes research and education into the challenges of creating technological futures that produce positive change in the world, focused on principles of equity, accountability, and care.

Games+Learning+Society (GLS) Center
One of the longest standing games-for-impact research & development centers in the world, GLS is the premier center for transdisciplinary research and innovation in games and interactive media for learning, behavioral and social change.

HPI Research Center in Machine Learning and Data Science at UCI
The Hasso Plattner Institute (HPI), dedicated to pioneering research into information technology, announced on Feb. 26, 2020 the opening of its newest research school, the HPI Research Center in Machine Learning and Data Science at UCI. The goal is to promote research and educational activities in these two fields between the two leading universities.

Institute for Future Health
Empowering individuals to preserve and promote health using technology.

IGB - Institute for Genomics and BioInformatics
Fostering innovative basic and applied research in genomics and BioInformatics, IGB works with established companies, start-ups, government agencies and standards bodies to develop and transition these technologies to widespread and practical application.

ISR - Institute for Software Research
Works toward advancing software and information technology through research partnerships and educating the next generation of software researchers and practitioners in advanced software technologies.

IVECG - Institute for Virtual Environments and Computer Games
Brings together researchers for the common goal of understanding and creating technology and applications that transform how we: see the world through immersive visualization and virtual tours; interact and socialize with global communities; communicate and collaborate with colleagues in virtual collaborative space; provide medical care and training to remote corners of the world; and educate all ages and populations using virtual environments.

LUCI - Laboratory for Ubiquitous Computing and Interaction
Addresses the entire range of research problems that arise from the ubiquitous computing vision: the design of novel devices, the structure of software systems, techniques for designing and building systems, patterns of interaction, and the cultural implications of ubiquitous computing.

Secure Systems and Software Laboratory
The Secure Systems and Software Laboratory at the University of California, Irvine.

SCONCE - Secure Computing and Networking Center
SCONCE focuses on research for protecting information and computing infrastructure with an emphasis in areas like applied cryptography, network security and information assurance.