MAP-Kinase in Solution
References
(1) Levchenko, A., Bruck, J., Sternberg, P.W. (2000). Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc. Natl. Acad. Sci. USA97(11):5818–5823.
(2) Shapiro, B, Leevchenko A., Mjolsness E. (2001) Automatic Equation Generation for Signal Transduction with Applications to MAP-Kinase, in Foundations of Systems Biology, Edited by H. Kitano, MIT Press.
Canonical Form
Define the System
Translate reactions into differential equations
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Predict a Time Course
