Zhaoxia Yu, Ph.D.
Associate Professor

Department of Statistics
University of California
Irvine, CA 92697-1250





Research Interests

Statistical methods and applications.


Current Teaching

I will be teaching Statistics 200C in Spring 2021.


Courses that I taught before: STAT8, STAT120ABC STAT120C, STAT140/240, STAT257, STAT262, STAT200ABC


Some Recent Work

o   Yu Z, Guindani M, Grieco SF, Chen L, Holmes TC, Xu X. (2021) Beyond t-Test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research. Neuron. (accepted)

o   Tong S, Johnston K, Lur G, Guidani M, Ombao H, Xu X, Yu Z. (2021) Time-varying ℓ0 optimization for Spike Inference from Multi-Trial Calcium Recordings. Submitted. arXiv preprint. arXiv:2103.03818

o   Pluta D, Xu X, Gillen D, Yu Z. (2021). A Measurement of In-Betweenness and Inference Based on Shape Theories. Submitted. arXiv preprint. arXiv:2103.09718

o   D'Angelo L, Canale A, Yu Z, Guindani M. (2021) Bayesian nonparametric analysis for the detection of spikes in noisy calcium imaging data. Revision submitted to Biometrics. arxiv preprint. arXiv:2102.09403

o   Tong S, Lur G, Xu X, Yu Z. (2021) To Deconvolve, or Not to Deconvolve: Inferences of Neuronal Activities using Calcium Imaging Data. Under revision at Journal Neuroscience Methods. arXiv preprint. arXiv:2103.02163

o   Brandt AU, Sy M, Bellmann-Strobl J, Newton BL, Pawling J, Zimmermann HG, Yu Z, Chien C, Dorr J, Wuerfel JT, Dennis JW, Paul F, Demetriou M (2021) Association of a Marker of N-Acetylglucosamine With Progressive Multiple Sclerosis and Neurodegeneration. JAMA Neurology. Published online May 10, 2021. doi:10.1001/jamaneurol.2021.1116

o   Pluta D, Shen T, Xue G, Chen C, Ombao H, Yu Z. (2020) Ridge-penalized adaptive Mantel test and its application in imaging genetics. To appear in Statistics in Medicine. arXiv preprint. arXiv:2103.02156

o   Johnston KG, Grieco SF, Yu Z, Jin S, Shen T, Crary R, Guzowski J, Holmes T, Nie Q, Xu X. (2020) Robust population single neuronal calcium signal extraction using SCOUT allows for longitudinal analysis of behavior-associated neural ensemble dynamics. Submitted doi: https://doi.org/10.1101/2020.08.26.268151

o   Grieco SF, Qiao X, Zheng X, Liu Y, Chen L, Zhang H, Yu, Z, Gavornik JP, Lai C, Gandhi SP, Holmes TC. (2020). Subanesthetic ketamine reactivates adult cortical plasticity to restore vision from amblyopia. Current Biology, 30(18), pp.3591-3603.

o   Feng J, Chen C, Cai Y, Ye Z, Feng K, Liu J, Zhang L, Yang Q, Li A, Sheng J, Zhu B, Yu Z, Chen C, Dong Q, Xue G. (2020) Partitioning heritability analyses unveil the genetic architecture of human brain multidimensional functional connectivity patterns. Human Brain Mapping. 41(12): 3305-3317.

o   Sy M, Brandt AU, Lee SU, Newton BL, Pawling J, Golzar A, Rahman AM, Yu Z, Cooper G, Scheel M, Paul, F. (2020). N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation. Journal of Biological Chemistry, 295(51), pp.17413-17424.


Older Articles (selected)

o   Pluta D, Yu Z, Shen T, Chen C, Xue G, Ombao H. (2018) Statistical Methods and Challenges in Connectome Genetics. Statistics and Probability Letters. 136:83-86

o   Interiano M, Kazemi K, Wang L, Yang J, Yu Z, Komarova NL. (2018) Musical trends and predictability of success in contemporary songs on and off the top charts. To appear in Royal Society Open Science, 5: 171274.

o   Wu K, Chen C, Moyzis RK, Nuno M, Yu Z, Greenberger E. (2018) More than Skin Deep: Uncovering Major Histocompatibility Complex (MHC)-Based Attraction among Asian American Speed-daters. Evolution and Human Behavior, 39(4):447-456.

o   Wu K, Chen C, Moyzis RK, Greenberger E, Yu Z. (2016) Gender Interacts with Opioid Receptor Polymorphism A118G and Serotonin Receptor Polymorphism -1438A/G on Speed-dating Success. Human Nature, 27(3):244-60.

o   Yu Z, Demetriou M, Gillen D. (2015) Genome-wide analysis of gene-gene and gene-environment interactions using closed-form Wald tests. Genetic Epidemiology, 39: 446-455. (software: GG_Wald)

o   Yu Z, Li CF, Mkhikian H, Zhou RW, Newton BL, Demetriou M. (2014) Family studies of Type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms. Genes and Immunity, 15:218-223.

o   Yu Z, Gillen D, Li CF, Demetriou M. (2013) Incorporating parental information into family-based association tests. Biostatistics, 14: 556-572.supplementary material

o   Yu Z (2012). Family-based association tests using genotype data with uncertainty. Biostatistics, 13:228-240.

o   Shahbaba B, Shachaf CM, Yu Z. (2012) A pathway analysis method for genome-wide association studies. Statistics in Medicine, 31:988-1000.

o   Yu Z, Deng L. (2011) Pseudosibship methods in the case-parents design. Statistics in Medicine, 30:3236-3251.

o   Yu Z, Wang S (2011). Contrasting linkage-disequilibrium as a multi-locus family-based association test. Genetic Epidemiology, 35:487-498.

o   Yu Z (2011). Testing gene-gene interactions in the case-parents design. Human Heredity, 71:171-179.

o   Weng L, Macciardi F, Subramanian A, Guffanti G, Potkin SG, Yu Z, Xie X. (2011) SNP-based pathway enrichment analysis for genome-wide association studies. BMC Bioinformatics, 12:99.

o   Browning B, Yu Z. (2009). Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false positive associations for genome-wide association studies. American Journal of Human Genetics, 85:847-861.

o   Yu Z, Garner C, Ziogas A, Anton-Culver H, Schaid D. (2009). Genotype determination for polymorphisms in linkage disequilibrium. BMC Bioinformatics, 10:63.

o   Yu Z, Wang L, Hildebrandt MAT, Schaid D. (2008). Testing whether genetic variation explains correlation of quantitative measures of gene expression, and application to genetic network analysis. Statistics in Medicine, 27:3847 - 3867.

o   Yu Z, Schaid D. (2007). Methods to impute missing genotypes for population data. Human Genetics, 122:495-504.

o   Yu Z, Schaid D. (2007). Sequential haplotype scan methods for association analysis. Genetic Epidemiology, 31: 553-564.

o   Levine R, Yu Z, Hanley W, Nitao J. (2005). Implementing componentwise Hastings algorithms, Computational Statistics & Data Analysis, 48: 363-389.

o   Levine R, Yu Z, Hanley W, Nitao J. (2005). Implementing the random scan Gibbs sampler, Computational Statistics, 20: 177-196

(taken in November 2018)