**Speeding up dynamic programming**.

D. Eppstein, Z. Galil, and R. Giancarlo.

*29th IEEE Symp. Foundations of Comp. Sci.,*White Plains, New York, 1988, pp. 488–496.

*Worksh. Algorithms for Molecular Genetics,*Bethesda, Maryland, 1988.

Tech. Rep. CUCS-379-88, Computer Science Dept., Columbia University, 1988.

Appeared as "Efficient algorithms with applications to molecular biology" in*Int. Advanced Workshop on Sequences,*Positano, Italy, 1988.

*Sequences: Combinatorics, Compression, Security, Transmission,*R. M. Capocelli, ed., Springer, 1990, pp. 59–74.The FOCS and Positano versions of this paper merged my results on a dynamic program used for RNA secondary structure prediction, with Raffaele's on sequence comparison. The Bethesda talk and the TR version both used the longer title "Speeding up dynamic programming with application to the computation of RNA structure", and included only the RNA result, which used a mild convexity assumption on certain costs to save two orders of magnitude in total time. This work incited a boom in computational biology within the theory community that is still going strong. But the RNA results were quickly improved by a log factor [Aggarwal et al. at the same FOCS] and never made it into a journal paper.

(Bibtex: Positano, FOCS – Citations – Citations of "Efficient algorithms..." – MIT hypertext bibliography – CiteSeer)

**Sparse dynamic programming**.

D. Eppstein, Z. Galil, R. Giancarlo, and G.F. Italiano.

*1st ACM-SIAM Symp. Discrete Algorithms,*San Francisco, 1990, pp. 513–522.

"Sparse dynamic programming I: linear cost functions",*J. ACM*39: 519–545, 1992.

"Sparse dynamic programming II: convex and concave cost functions",*J. ACM*39: 546–567, 1992.Considers sequence alignment and RNA structure problems in which the solution is constructed by piecing together some initial set of fragments (e.g. short sequences that match exactly). The method is to consider a planar point set formed by the fragment positions in the two input sequences, and use plane sweep to construct a cellular decomposition of the plane similar to the rectilinear Voronoi diagram.

(BibTeX – Citations to conference version – Citations to SDP I – Citations to SDP II)

**Efficient algorithms for sequence analysis**.

D. Eppstein, Z. Galil, R. Giancarlo, and G.F. Italiano.

*International Advanced Workshop on Sequences,*Positano, Italy, 1991.

*Sequences II: Methods in Communication, Security, and Computer Science,*R.M. Capocelli, A. De Santis, and U. Vaccaro, eds., Springer, 1993, pp. 225–244.

Surveys results on speeding up certain dynamic programs used for sequence comparison and RNA structure prediction.

(BibTeX – Citations – CiteSeer)

Co-authors – Publications – David Eppstein – Theory Group – Inf. & Comp. Sci. – UC Irvine

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